منابع مشابه
Regulation of HIV gene expression.
The quantity and quality of HIV-1 gene expression is temporally controlled by a cascade of sequential regulatory interactions. Basal HIV-1 transcription is determined by interaction of cellular regulatory proteins with specific DNA target sequences within the HIV-1 long-terminal repeat. The most notable of these protein:DNA interactions involves NF-kappa B, a transcription factor that plays a p...
متن کاملDynamic Post-Transcriptional Regulation of HIV-1 Gene Expression
Gene expression of the human immunodeficiency virus type 1 (HIV-1) is a highly regulated process. Basal transcription of the integrated provirus generates early transcripts that encode for the viral products Tat and Rev. Tat promotes the elongation of RNA polymerase while Rev mediates the nuclear export of viral RNAs that contain the Rev-responsive RNA element (RRE). These RNAs are exported fro...
متن کاملTranscriptional and posttranscriptional regulation of HIV-1 gene expression.
Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat stimulates transcription elongation by directing the cellular transcriptional elongation factor P-TEFb to nascent RNA polymerases. Rev is required for the transport from the nucleus to the cytoplasm of the unspliced and incompletely spliced mRNAs that encode the structural proteins of the virus. Molecula...
متن کاملRegulation of HIV and HTLV gene expression.
Until recently, simplicity and uniformity of design appeared to be universal features of retroviruses. Most retroviruses thrive with a few open reading frames in their genomes, all devoted to major constituents of virus particles: core proteins, envelope glycoproteins, and virionassociated catalytic proteins (reverse transcriptase, integrase, and protease). In the life cycle of the usual retrov...
متن کاملSRSF1 inhibition of HIV-1 gene expression
The treatment of HIV-1 infected patients is mostly based on compounds that directly target the activity of proteins coded by the virus. However, the viral genome mutates at a rapid rate, generating drug resistant strains, hence the need for novel drugs to outpace the adaptive mechanisms of the virus. Since cellular factors, which are required for the efficient expression of the HIV-1 genome, do...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2013
ISSN: 1742-4690
DOI: 10.1186/1742-4690-10-s1-o16